This post is a very long answer to Josie's question in the last post, where she asked me how I picked my myo-insoitol dose. Well here goes my experience with this so far. Just some background information you need: In most studies, women receive 2000 mg myo-inositol twice a day, along with folic acid, in a prescription preparation, Infolic.
My experience with this supplement
Despite being aware of the dose used in studies, I arbitrarily went with a lower dose initially because, well, I was nervous about what it would do. I started with 1000 mg/day, of supplemental (and not the prescription preparation myo-inositol) and things looked great that cycle...I ovulated a bit later (CD 19) than my recent cycles (O day in the past year, has been CD 17).
Just FYI, in my pre-vitamin D, pre-supplement days, my best-looking ovulations were on CD 20. Sadly, none of my pregnancies were conceived during these cycles, they happened in shorter, crappier-looking cycles where I ovulated on CD 16.
Anyway, coming back to the present day, after that first great-looking cycle (with a nearly 16 day luteal phase) where I was taking 1000 mg/day, I shifted to 2000 mg/day, and stuff pretty much went to hell the next cycle--no EWCM, or CM of any sort, no detectable LH surge. I was not even sure I'd ovulated, except my temperature did go up. The luteal phase was a markedly short 11 days.
Alarmed, I shifted back to the 1000 mg dose. The next cycle (still ongoing) is interesting...there was one alarming day where my temperature short up, making me think I had ovulated, and prompting my last post. But happily, I was wrong, I have not misplaced my surge, this turned out to be a nice-looking cycle; got lots of CM, did show a strong surge, ovulated a bit late (on CD 22).
So...phew.It looks like Myo-inositol may not be bad for me, but only at low doses. It has changed my O date Still have not settled into a pattern, but it will be interesting. How many women, if nothing changes, ovulate on a certain day every month? I'd really like to know.
Also, if you are a PCOSer, or a non-PCOS infertility case on myo inositol, I'd really love to hear your experience. Please do share, sometimes anecdotal information can also be useful!
Also, some information to note, if part of your issue is low progesterone, this may really be something to try out, since both published literature and my experience (with the 1000 mg/day dose) suggest that this really can increase progesterone levels.
Updated: I did an IVF cycle a few months after this post. Myo-inositol is supposed to increase the percentage of oocytes that are mature at pickup. We got 14 M2 eggs, 2 M1 eggs, and 3 that crapped out, from a total of 19 follicles.All my M2s and my M1s fertilized too.
Overall, this was pretty darned amazing: My first IVF---where the protocol used on me was far from ideal---produced 4 m2 and a few M1 eggs out of 11, and only 3 M2s fertilized---interestingly, none of my M1s fertilized, in contrast to my second cycle.
I attribute the improvement from IVF 1 to IVF 2 to 2 things: a very different protocol, and maybe, in part, the myo-inositol.
My experience with this supplement
Despite being aware of the dose used in studies, I arbitrarily went with a lower dose initially because, well, I was nervous about what it would do. I started with 1000 mg/day, of supplemental (and not the prescription preparation myo-inositol) and things looked great that cycle...I ovulated a bit later (CD 19) than my recent cycles (O day in the past year, has been CD 17).
Just FYI, in my pre-vitamin D, pre-supplement days, my best-looking ovulations were on CD 20. Sadly, none of my pregnancies were conceived during these cycles, they happened in shorter, crappier-looking cycles where I ovulated on CD 16.
Anyway, coming back to the present day, after that first great-looking cycle (with a nearly 16 day luteal phase) where I was taking 1000 mg/day, I shifted to 2000 mg/day, and stuff pretty much went to hell the next cycle--no EWCM, or CM of any sort, no detectable LH surge. I was not even sure I'd ovulated, except my temperature did go up. The luteal phase was a markedly short 11 days.
Alarmed, I shifted back to the 1000 mg dose. The next cycle (still ongoing) is interesting...there was one alarming day where my temperature short up, making me think I had ovulated, and prompting my last post. But happily, I was wrong, I have not misplaced my surge, this turned out to be a nice-looking cycle; got lots of CM, did show a strong surge, ovulated a bit late (on CD 22).
So...phew.It looks like Myo-inositol may not be bad for me, but only at low doses. It has changed my O date Still have not settled into a pattern, but it will be interesting. How many women, if nothing changes, ovulate on a certain day every month? I'd really like to know.
Also, if you are a PCOSer, or a non-PCOS infertility case on myo inositol, I'd really love to hear your experience. Please do share, sometimes anecdotal information can also be useful!
Also, some information to note, if part of your issue is low progesterone, this may really be something to try out, since both published literature and my experience (with the 1000 mg/day dose) suggest that this really can increase progesterone levels.
Updated: I did an IVF cycle a few months after this post. Myo-inositol is supposed to increase the percentage of oocytes that are mature at pickup. We got 14 M2 eggs, 2 M1 eggs, and 3 that crapped out, from a total of 19 follicles.All my M2s and my M1s fertilized too.
Overall, this was pretty darned amazing: My first IVF---where the protocol used on me was far from ideal---produced 4 m2 and a few M1 eggs out of 11, and only 3 M2s fertilized---interestingly, none of my M1s fertilized, in contrast to my second cycle.
I attribute the improvement from IVF 1 to IVF 2 to 2 things: a very different protocol, and maybe, in part, the myo-inositol.
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